Lee Parkin 1916–2013

Lee 25_8

4-Hydroxynonenal (4-HNE) is a peroxidation product of ˆ-6-poly-unsaturated fatty acids and exerts growth modifying as well as cytotoxic activities. This aldehyde component of oxidized lipid is increased during the aging process. In this study, to characterize the potential role of the lipid peroxidation product in aging, we studied the effects of 4-HNE on cell proliferation and activation of ce...

Lee McIntyre

I Over the last decade or so, much has been written about the new "science of complexity". From journalistic hyperbole to cutting edge research, it is widely assumed that the science of complexity has indeed discovered something new, that is worthy of the attention of scientists and philosophers alike. But what? An overarching principle that connects the study of complex systems across the phys...

PINK1-Mediated Phosphorylation of Parkin Boosts Parkin Activity in Drosophila

Two genes linked to early onset Parkinson's disease, PINK1 and Parkin, encode a protein kinase and a ubiquitin-ligase, respectively. Both enzymes have been suggested to support mitochondrial quality control. We have reported that Parkin is phosphorylated at Ser65 within the ubiquitin-like domain by PINK1 in mammalian cultured cells. However, it remains unclear whether Parkin phosphorylation is ...

199904PPA Lee

dontic treatment is compounded by the necessity of utilizing an indirect approach, where fabrication occurs extraorally at the dental laboratory and the completed restorations are subsequently retrofitted in the oral cavity. One fundamental aspect in the fabrication of indirect restorations is the procurement of an accurate impression from which a refractory model can be created to precisely re...

Erin Lee